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Symbol
Name
ID

Mpl
myeloproliferative leukemia virus oncogene
MGI:97076

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Increased circulating IgA level	Increased circulating IgE level	Leukocytosis	Hemophagocytosis	Acute leukemia	Acute myeloid leukemia	Chronic myelogenous leukemia	Myeloproliferative disorder	Splenomegaly	Eczematoid dermatitis
Disease(s) Associated with MPL	Increased circulating IgA level	Increased circulating IgE level	Leukocytosis	Hemophagocytosis	Acute leukemia	Acute myeloid leukemia	Chronic myelogenous leukemia	Myeloproliferative disorder	Splenomegaly	Eczematoid dermatitis
essential thrombocythemia
myelofibrosis
thrombocytopenia

Mouse Phenotypes		immune system phenotype	enlarged spleen	decreased leukocyte cell number	abnormal circulating cytokine level	abnormal circulating chemokine level
Availability	Mouse Genotype	immune system phenotype	enlarged spleen	decreased leukocyte cell number	abnormal circulating cytokine level	abnormal circulating chemokine level
	Mpl^hlb219/Mpl^hlb219
	Mpl^tm1Mwm/Mpl^tm1Mwm	*
	Mpl^tm1Wsa/Mpl^tm1Wsa	*
	Mpl^tm2.1Wsa/Mpl^tm2.1Wsa Tg(Pf4-icre)Q3Rsko/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23